Kaha Sciences 遥测解决方案 结合了无线充电和最先进的压力传感器技术,可在心血管研究中提供无与伦比的准确性和长期记录。
可选择测量压力(动脉、静脉和心室)、ECG、交感神经活动和组织氧浓度 - Kaha Sciences 的植入子允许您在全部的实验过程中测量一系列心血管信号,来满足您的研究需求。
相关: 在研究中使用遥测的好处 »
Kaha Sciences 遥测 – 心血管应用:
压力
Kaha Sciences 大鼠压力植入子在导管尖端使用 Millar Mikro-Tip® 固态传感器技术,以实现高保真、准确和可重复的压力记录。2 Fr (0.66 mm) 传感器可以记录一系列压力,包括: 动脉压、静脉压和心室压。
相关: 使用固态压力传感器的好处»
植入子可提供长度为 9、15 或 25 厘米的单压力 (TRM54P) 或双压力 (TRM54PP) 导管,因此客户可以定制他们的实验并使用一个植入子记录多达两个压力。
信号的质量和准确性让人们在采集动物的基本功能(例如收缩压、舒张压)时充满信心,但也促进了更复杂的分析,例如频谱分析,来自血压的心输出量以及来自左心室压的 dP/dt 计算。
阅读更多: 成功记录大鼠遥测血压的提示和技巧»
文献:
- Sachdeva, R. et al. Noninvasive Neuroprosthesis Promotes Cardiovascular Recovery After Spinal Cord Injury. Neurotherapeutics (2021).
- Han, J.-C. et al. Left-Ventricular Energetics in Pulmonary Arterial Hypertension-Induced Right-Ventricular Hypertrophic Failure. Front. Physiol. 8, 1115 (2018).
- Griffiths, P. R. et al. Blockade of Rostral Ventrolateral Medulla Apelin Receptors Does Not Attenuate Arterial Pressure in SHR and L-NAME-Induced Hypertensive Rats. Front. Physiol. 9, 1488 (2018).
- Stehlin, E. et al. Chronic measurement of left ventricular pressure in freely moving rats. J. Appl. Physiol. 115, 1672–1682 (2013).
ECG
生物电植入子 (TR50B and TR50BB)允许长期记录自由活动大鼠的 心电图, 肌电图, 或 脑电图 。我们的无线充电技术支持长期,高采样率 (2kHz) 连续记录,非常适合监测自发的病理生理活动,例如 异位搏动 或 心律失常的产生。
TRM54PB 植入子还允许客户测量同一动物的 心电图 和 压力 来评估心脏和心血管功能。
文献:
- Kim, N. K., Wolfson, D., Fernandez, N., Shin, M. & Cho, H. C. A rat model of complete atrioventricular block recapitulates clinical indices of bradycardia and provides a platform to test disease-modifying therapies. Sci. Rep. 9, 6930 (2019).
- Zhang, D. et al. Reduced N‐Type Ca 2+ Channels in Atrioventricular Ganglion Neurons Are Involved in Ventricular Arrhythmogenesis. J. Am. Heart Assoc. 7, (2018).
交感神经活动 (SNA)
TRM56SP 植入子允许用户同时记录同一动物的血压和 SNA。这对研究高血压的发展和心血管控制特别有用。
SNA 导线的输入量程为 ±60µV,非常适合从纤细的外周自主神经进行活动记录。
文献:
- McBryde, F. D., Liu, B. H., Roloff, E. V., Kasparov, S. & Paton, J. F. R. Hypothalamic paraventricular nucleus neuronal nitric oxide synthase activity is a major determinant of renal sympathetic discharge in conscious Wistar rats. Exp. Physiol. 103, 419–428 (2018).
- Salman, I. M., Sarma Kandukuri, D., Harrison, J. L., Hildreth, C. M. & Phillips, J. K. Direct conscious telemetry recordings demonstrate increased renal sympathetic nerve activity in rats with chronic kidney disease. Front. Physiol. 6, (2015).
组织氧
TR57Y 组织氧植入子 是市场上唯一可以实时测量清醒大鼠组织氧浓度的设备。
植入子使用一个稳定的碳糊电极,可以测量肾脏和大脑的局部 缺血 和 组织代谢活动。结合我们的无线充电技术,研究人员能够 24/7 全天候记录和评估肾脏组织氧含量的昼夜节律变化。
文献:
- Thakkar, P.C. et al. Therapeutic Relevance of Elevated Blood Pressure After Ischemic Stroke in the Hypertensive Rats. Hypertension. 75, 740–747 (2020)
- Adamovich, Y. et al. Oxygen, and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals. Cell Metab. 29, 1092-1103.e3 (2019).
- Emans, T. W., Janssen, B. J., Joles, J. A. & Krediet, C. T. P. Circadian Rhythm in Kidney Tissue Oxygenation in the Rat. Front. Physiol. 8, (2017).
有关 Kaha Sciences 植入子的更多信息,或讨论您的特定研究应用,请联系离您最近的 ADInstruments 支持代表。
相关资源:
Looking for a platform to integrate all your recording devices? Get a LabChart 8 demo today!
LabChart data analysis software creates a platform for all of your recording devices to work together, allowing you to acquire biological signals from multiple sources simultaneously and apply advanced calculations and plots as your experiment unfolds. With a wide range of features and extensions and specialized research modules, LabChart 8 is trusted by scientists worldwide.
More about LabChart 8 »
Try the latest LabChart iteration - LabChart Lightning! »